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Chunk #44 — Background — Description of clinical characteristics of KPD and how the family data were collected and classified

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Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.
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8. Together with the anxiety caused by weather is an extreme sensitivity to what patients describe as ''cold'' (e.g., 20 degrees Celsius or less) or ''hot'' (27 degrees Celsius or more). But patients can have paradoxical reactions to ambient conditions. Some cannot bring themselves to dress ''appropriately'' for their perceived sensitivity, i.e., they will not wear, and show a strong aversion to, warm clothing. Many prefer to shiver, complain and obsess about the weather, even (or especially) in areas that have no weather. This symptom may be related to thoughts that dwell on body habitus (see below). Others will dress in goosedown clothing in weather the normal population would consider perspiration-inducing. Thus, KPD patients will sometimes arrive for their appointments looking like the ''Michelin Man,'' in their down vests and jackets, even when the weather is balmy, and arrive in swim attire even when the temperature is not particularly high. This latter is seen especially in men with high abdominal muscle definition (see below, under ''body habitus'').