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Chunk #45 — Background — Description of clinical characteristics of KPD and how the family data were collected and classified

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Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.
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9. A preoccupation with body habitus, both of the patient's own and with that of others. In male sufferers, this can manifest as an extreme concern with definition of abdominal muscles ("washboard abs," "sixpack"). These patients have a notable comorbidity for steroid drug use. In women, this same tendency can manifest as an obsession with body weight, or concern about perceived, often imagined, "defects". Elective surgery or other medical intervention changing body or specific organ appearance/prominence is frequently sought by KPD sufferers, and thus morbidity associated with these operations is more frequent among KPD patients. Female sufferers may exhibit anorexia/bulimia. KPD patients may have a mild form of Body Dysmorphic Disorder (DSM-IV 300.7).