Childhood adversity was associated with a higher number of maxdrinks in AA women, AA men, and EA women, with odds ratios ranging from 1.67 (1.32–2.12) to 1.92 (CI: 1.45–2.53). For AUD symptoms, main effects of childhood adversity were evident only in African-Americans (OR=1.71, CI: 1.31–2.22 for women and OR=1.78, CI: 1.41–2.25 for men). A moderating effect of childhood adversity on the association between ADH1B variants and alcohol outcomes was observed exclusively in EA men for AUD symptoms. Exposure to childhood adversity was associated with a significant increase in risk for AUD symptoms in carriers of the A (His) allele in rs1229984 (OR=3.16 (1.32*2.39), CI:1.64–6.09; p=0.017); that is, the protective effect of the A allele was significantly reduced in EA men who had experienced childhood adversity. Mean AUD symptoms by genotype and childhood adversity status in EA men are shown with 95% confidence intervals in Figure 1. Carriers of the A allele who did not endorse adverse childhood experiences reported a mean of 3.6 (SD=3.3) AUD symptoms, whereas those who endorsed adverse childhood events reported a mean of 6.3 (SD=2.9) symptoms,
