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Chunk #36 — Materials and Methods — Statistical analyses

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Sex differences in genetic architecture of complex phenotypes?
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When the DZos correlation was significantly lower than the DZss correlation, an additional set of analyses was carried out to estimate variance components due to Additive genetic effects (A), Common environmental effects (C) and unique Environmental effects (E). The analysis of twin data rests critically on several assumptions. One is that the environmental components of variance are the same in the two types of twins (MZ versus DZ) and another one that the total genetic variance is the same in the two types [1]. These and other assumptions are addressed in more detail in van Dongen et al [25]. In general, the empirical evidence suggests that these assumptions are reasonable.