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Chunk #37 — Materials and Methods — Statistical analyses

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Sex differences in genetic architecture of complex phenotypes?
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yes

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For the traits that showed sex differences in the saturated model, additional model fitting was carried out. First a full model that allowed the magnitude of A, C and E to be different in men and women was fitted to the data. In this model, the genetic correlation in DZos twins (γ) was allowed to be smaller than 0.5 (or if the C component was much larger than the A component, the shared environmental correlation in DOS twins (φ) was allowed to be smaller than 1). It should be noted that there is a particular problem in trying to differentiate between γ and φ, these are confounded and can only be estimated by making some very strong assumptions.