Data on drug gene targets, indications, latest development phase, and approvals by country were collected from the Informa Pharmaprojects database (accessed January 25, 2018) [14]. For each drug, Pharmaprojects provides country-level, indication-level, and global development status. The latter is the latest development status across indications for any country. A drug was considered US/EU approved for an indication if it was approved in the US or EU and approved for that indication (so if a drug is US/EU approved for one but not all of its approved indications, we will incorrectly assign some approvals). We infer this was also the approach of Nelson et al., as they mention no source other than Pharmaprojects for drug approval data and Pharmaprojects does not provide drug-indication-country level approval data.
