Voxel-wise analyses were conducted to isolate brain regions associated with differential sensitivity to positive versus negative high-arousal stimuli. In LSSs, the right putamen showed greater sensitivity to negative than to positive high-arousal stimuli, whereas the left putamen showed greater sensitivity to positive than to negative high-arousal stimuli (Table 1). HSSs did not show significant differential activation to positive versus negative high-arousal stimuli. In the left putamen, lower Disinhibition scores on the Zuckerman Sensation-Seeking Scale Form V predicted greater fMRI sensitivity to valence (Fig. 2c, Table 2), and the correlation with the ZKPQ Sensation Seeking scale was significant and negative (r = −.437, p < .005).
