The time course of the fMRI signal in these three regions (as well as the posterior medial OFC) was examined for group differences in latency and amplitude of the peak fMRI response to high-arousal stimuli relative to baseline. In the right insula/IFG, the peak response was higher in magnitude for HSSs than for LSSs (Fig. 1d). In the left anterior cingulate cortex and anterior medial OFC, the peak response for high-arousal stimuli occurred earlier in LSSs than in HSSs (Figs. 1e and 1f). In addition, the response in the anterior medial OFC was more robust in LSSs.
