with the ZKPQ Sensation Seeking scale was not significant in either of these two regions (p > .17). The posterior medial orbitofrontal cortex region (not included in Fig. 1) showed a response similar to that of the right insula/IFG region in Figure 1a, with greater activation in response to high-arousal stimuli among HSSs than among LSSs, but the interaction of arousal and sensation seeking was only marginally significant.