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Chunk #21 — 2. Results

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Whole genome association scan for genetic polymorphisms influencing information processing speed.
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The results for SNPs exceeding suggestive significance level are shown in Table 2; see Appendix CSupplementary Table 1 for top 100 SNPs. For digit symbol, six SNPs showed suggestive significance with three of these SNPs in strong linkage disequilibrium (LD) with each other; they were located in or nearby two known genes, ATRNL1 and KRTAP7-1, although none were exonic. Eight SNPs in three genes were shown to be associated (at suggestive levels) with symbol search in the LBC1936 cohort. The effect sizes of these SNPs were relatively large, ranging between .21 and .43, but larger standard errors accompany these estimates demonstrating the reduced power of the analysis for individual cohorts. There were five SNPs that passed the suggestive significance criterion for inspection time, and two of these were located in a single known gene, CRTC3. For simple RT, 11 SNPs were identified at the suggestive level of significance, with a SNP on chromosome 3 located in MYRIP. For 2-choice RT mean, 10 SNPs (on 6 chromosomes and two in DCDC2) showed suggestive association. The beta weights for all top SNPs