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Chunk #22 — 2. Results

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Whole genome association scan for genetic polymorphisms influencing information processing speed.
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were identified at the suggestive level of significance, with a SNP on chromosome 3 located in MYRIP. For 2-choice RT mean, 10 SNPs (on 6 chromosomes and two in DCDC2) showed suggestive association. The beta weights for all top SNPs for each trait were homogenous between cohorts (p > .05). For 4-choice RT, five SNPs showed suggestive significance, they were located in FAM110C, DIP2C and KCTD2. In the Australian cohort, the majority of SNPs showing suggestive association with 8-choice RT mean were in almost perfect LD with each other. SNPs on five chromosomes were identified and two known genes were implicated (RAB11F1P2, LAPTM4A). Minor allele frequencies were above .07 and effect sizes ranged between .18 and .41. Six SNPs were suggestively significant for the processing speed factor; some were located in PDE1C and PKNOX1 genes. Only one SNP (rs1375785) showed suggestive association with multiple measures (2- and 8-choice RT).