Chunk #33 — Results — COL6A3: Regulation of ethanol sensitivity in C. elegans and correlation with handling-induced convulsions in mice

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Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

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We tested three C. elegans genes with equally high orthology to human COL6A3 for effects on initial sensitivity and AFT. RNAi knockdown of C16E9.1 decreased initial sensitivity compared to control RNAi animals (p<0.05, Figure 4A) but did not affect the development of AFT. RNAi knockdown of the other COL6A3 orthologs (C18H7.1 and cutl-23) produced no significant differences in either measure (Figure 4B,C). Statistics and uncorrected basal speed data for all C. elegans experiments are shown in Supplementary Table S6.