Chunk #34 — Results — COL6A3: Regulation of ethanol sensitivity in C. elegans and correlation with handling-induced convulsions in mice

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Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

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In mice, Col6a3 is located within the Alcw5 QTL interval (MGI:3037048) for handling-induced convulsions (HIC) following 72 hour ethanol vapor exposure (Bergeson et al., 2003). The Alcw5 QTL maps to 39.16 centiMorgans (cM) on mouse chromosome 1, with a support interval of 28–47 cM. After converting cM to megabase pairs (Mb) for the latest version of the mouse genome (GRCm38/mm10), this yields a physical location of the Alcw5 QTL peak of 75.57 Mb and a QTL support interval of 62.12–107.66 Mb. Col6a3 is located at mouse chr1:90766860–90843971, within the defined Alcw5 QTL support interval.