In the trans-ancestry GWAS meta-analysis of the OEcontrols phenotype comparison, we identified GWS loci in the single-variant and the gene-based analyses. No external validations were observed for rs12461856 and further studies will be needed to confirm this finding. Conversely, SDCCAG8 identified in the gene-based analysis (but not related to any individual GWS variants) was shown in studies available in the GWAS catalog48 to have 49 single-variant associations with educational attainment49, blood-related parameters50, risk-taking behaviors34, anthropometric traits44, kidney function51, and schizophrenia52. The previous associations with behavioral traits support SDCCAG8 as potentially associated with behaviors that, in turn, associated with increased risk of OE.
