A further example voxelwise analysis is shown in Supplementary Fig 1, where the rfMRI data was used to investigate aging effects in the default-mode resting-state network25. This also provides a demonstration that group analyses do not degrade with increasingly-large subject numbers (e.g., due to alignment issues), using group sizes from 15 to 5000. With increasing subject numbers, background noise is suppressed without increase in spatial blurring, and localized estimates of age-dependence stabilize, with statistical significance rising indefinitely.
