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Chunk #9 — Results — Alcohol rapidly and specifically downregulates a subset of pre-existing BK mRNA variants

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Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.
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Thus, alcohol exposure reduced the number of BK mRNA variants by eliminating several variants, five out of six of them containing exon 29. Due to its regulation by alcohol we refer to exon 29 as ALCOREX (alcohol-regulated exon), by analogy to STREX (stress axis-regulated exon - Xie and McCobb, 1998). Sequences of products of both exons (ALCOREX and STREX) and their positions in the BK polypeptide are shown in Figure 1E.