In males, the regression coefficient for EXT-GR began low at age 12 (β= −0.005 [−0.037; 0.026], p-value=0.745), rose significantly (p-value<0.001) at age 14 (β=0.121 [0.050; 0.191], p-value<0.001), decreased nominally at age 17 (β= −0.021 [−0.120; 0.079], p-value=0.684), and then nominally rose to its peak at age 22 (β=0.166 [0.013; 0.319], p-value=0.034); the differences between age 14 and later ages were not significant. In contrast, AUD-GR started at a low value at age 12 (β=0.010 [−0.035; 0.015] p-value=0.435) and reached a peak value at age 22 (β=0.250 [0.131; 0.369], p-value<0.001); the differences between age 12 and age 22 were statistically significant (p-value<0.001), while other age comparisons were not significant. The relationship between AUD-GR, EXT-GR, and the alcohol use behaviors over development for males is depicted in Figure 2.
