In females, the regression coefficient for EXT-GR began low at age 12 (β= −0.027 [−0.050; −0.004], p-value=0.024), rose to a peak at age 14 (β=0.134 [0.065; 0.202], p-value<0.001), and then decreased nominally from age 17 (β=0.126 [0.040; 0.212], p-value=0.004) through age 22 (β= −0.005 [−0.156; 0.147], p-value=0.953). Age 12 and age 22-point estimates were significantly different from age 14 and 17-point estimates only. In contrast, AUD-GR started at a similarly low value at age 12 (β= −0.025 [−0.041; −0.008], p-value=0.005) that increased significantly (p-value<0.001) at age 14 (β=0.075 [0.024; 0.126], p-value=0.004), and age 17 (β=0.130 [0.069; 0.191], p-value=0.001) and reached its peak at age 22 (β=0.140 [0.029; 0.251], p-value=0.014); the differences between age 14 and later ages were not significant. The relationship between AUD-GR, EXT-GR, and the alcohol use behaviors over development for females is depicted in Figure 2.
