On the other hand, different pharmacodynamic rather than psychological mechanisms of action have been proposed to explain the success of disulfiram in cocaine addiction [9], [10], [11], and in one case report of pathological gambling [12]. Several studies have proposed that cocaine use is reduced in subjects taking disulfiram because disulfiram inhibits dopamine beta-hydroxylase (DBH) and the consequent reduction of synaptic norepinephrine release alters the “high” [13], [14], [15], [16].
