The significant results (p < 5 × 10−8) of the GWAS of AUDIT total score in the UKB cohort are shown in Supplementary Table 9; this analysis revealed 12 independent GWAS signals located in 8 loci. The UKB GWAS of AUDIT-C and AUDIT-P subsets are summarized in Supplementary Tables 10 and 11 and Supplementary Figure 4. Seven of these 12 independent GWAS signals also significantly associated with AUDIT-C; the same index variants were identified in the two analyses. An additional GWAS signal was also identified close to FNBP4. For AUDIT-P, 5 independent GWAS signals were significantly associated and these loci were also associated with the total AUDIT and AUDIT-C. The rs1229984 SNP in ADH1B was not available for meta-analysis in the 23andMe sample and was not in Hardy Weinberg equilibrium (HWE) in the UKB sample used in the present study (p = 3.2 × 10−16); however, in the total UKB White British sample there was no significant deviation from HWE (p = 0.13). The association between rs1229984 and AUDIT scores are presented in Supplementary Tables 9, 10 and 11. rs1229984
