Chunk #102 — Online Methods — Power calculation for somatic mutation detection in cancer tissue samples

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Absolute quantification of somatic DNA alterations in human cancer.

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Power for expected subclonal variants present in fraction sf of cancer cells is given by Pow(n, sfδτ) This calculation was used for Supplementary Fig. 7c,e. Local copy calculations using Pow(n, sfδ) were used for Supplementary Figs. 7f, 11.