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Chunk #10 — Online Methods — eQTL Analyses — Liver, subcutaneous, and omental fat tissue

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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
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The determination of eQTLs in liver, subcutaneous and omental fat tissue have been described in detail previously13. In brief, liver, subcutaneous, and omental fat tissue were obtained from patients of European ancestry who underwent bariatric surgery. Expression of a total of 39,280 oligonucleotide probes targeting transcripts representing 34,266 known and predicted genes was assessed. All patients were genotyped on a genome-wide SNP array and association between SNPs and gene expression data was adjusted for age, race, gender, and surgery year using linear regression. Results are presented in Supplementary Table 14 and Supplementary Figure 4.