We examined the cis-associations (defined as genes within 1 Mb) between each of the BMI SNPs and expression of nearby genes in brain (cortical tissue)14. The eQTL analyses have been described in detail previously (GEO database: GSE8919)14. In brief, DNA and RNA of neuropathologically normal cortical brain samples of 193 individuals (average age [range]: 81 [65–100] yrs) of European ancestry were isolated and genotyped for a genome-wide SNP array and HapMap genotypes were imputed. RNA expression was assessed for 24,357 transcripts of which 14,078 transcripts met the QC criteria. Association analyses between SNPs and expression data assumed an additive model and were adjusted for sex and age at death. Results are presented in Supplementary Table 14 and Supplementary Figure 4.
