mOFC) and dACC; dACC task-related activation before MPH administration was correlated with shorter lifetime alcohol use137 (FIG. 4). Although it remains to be studied whether or how the noradrenergic effects of MPH contribute to its ‘normalizing’ effects in cocaine users, taken together these results suggest that the dopamine-enhancing effects of MPH could be used to facilitate changes in behaviour in addicted individuals (for example, improve self-control), particularly if MPH treatment is combined with specific cognitive interventions.
