It should be noted that the effect of dopamine agonists on normalizing brain–behaviour responses to emotional or cognitive-control challenges may depend on patterns of compulsive drug use126 or other individual differences, such as baseline self-control and lifetime drug use, but these possibilities remain to be studied in larger sample sizes. Also, non-dopaminergic probes (for example, cholinergic or AMPA receptor agonists) may offer additional pharmacological targets for cocaine addiction treatment138.
