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Chunk #44 — Materials and Methods — Simulation study — A simulated dataset with extended pedigrees

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A general approach for haplotype phasing across the full spectrum of relatedness.
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We also ran Merlin and our duoHMM method on these datasets to detect recombination events on all informative meioses which allowed us to investigate the sensitivity and specificity of the methods in both a realistic and ideal scenario. In the realistic and ideal simulations, there were 183 and 212 informative meioses containing a total of 2422 and 3131 crossover events (across all simulations) on which to evaluate accuracy.