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Chunk #45 — Materials and Methods — Simulation study — A simulated dataset of uninformative duos

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A general approach for haplotype phasing across the full spectrum of relatedness.
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The ability to detect recombination events is enhanced if an individual is part of a large pedigree. Such pedigrees will contain parent-child relationships where the parent's heterozygous sites can be phased independently of that child's loci (such as from a grandparent or another child) this allows changes in the pattern of inheritance (recombination events) to be detected. Previous work on detecting recombination events in pedigrees have used such informative pedigrees [37], [39], [41], [46]. We wanted to assess the power of our method to detect recombination events in uninformative duos.