To investigate whether differentially expressed genes between OCD subjects and unaffected comparison subjects were enriched for biologically relevant gene-set pathways, we used the gene set enrichment analysis (GSEA) platform39. This platform contains various molecular signature databases (MSigDB, v7.0;40), including curated gene sets that are publicly available and biologically relevant. Enrichment was evaluated on the differentially expressed genes from the analysis of all brain regions together and per individual brain region (MSigDB sets used are given in Supplement 1).
