Chunk #11 — Methods — Differential expression

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Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder.

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To identify drivers of variation in gene expression, the relationship between gene expression values and covariates—diagnosis, sex, age, post-mortem interval, pH, RNA integrity number, or brain region—were assessed using generalized linear regression38 (see Supplement 1 for details).