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Chunk #42 — STAR★METHODS — QUANTIFICATION AND STATISTICAL ANALYSIS — Joint analysis model for ancestrally diverse cohorts

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
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variants as predictors. Due to computational limitations, the Million Veterans Program was partitioned into 19 batches, which were then combined using an inverse variance weighted meta-analysis, implemented in METAL. To derive an estimate of the odds ratio (OR) and its standard error from the score test, the following conversion algorithm was applied: 1) logOR = Score/Variance, and 2) SE = 1/sqrt(Variance).61