In the present experiment, the data suggested the inverse. That is, the relative difference between responses to AO and responses to non-alcohol-related odors was larger with exposure to alcohol, at least in the abusive drinkers studied here. In fact, the orbital area showing this effect (34, 34, −14) was highly similar to areas identified by others as showing effects related to satiety (Gottfried et al., 2003; [24, 33, −12]; Kringelbach et al., 2003; [−22, 34, −8], although somewhat more anterior to the satiety-specific regions reported by O’Doherty et al. (2000; [18, 18, −17]). Similar to Gottfried et al. (2003), we also found that activation induced by the sensory properties of a reward was sensitive to reward satiety in the ventral striatum and cingulate cortex. We believe that, in these hazardous drinkers, the relatively greater response to the AO compared to control odors reflects the reinforcing effects of the priming alcohol, and increased desire to drink following that prime (De Wit, 1996; De Wit and Chutuape, 1993) particularly insofar as the targeted BrAC of 0.05 would be a relatively low concentration
