Chunk #89 — III. Selected Methodological Issues — A. Genotyping using pooled DNAs

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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4. Validation studies assess the fits between individual and pooled genotyping in a number of different ways. These include assessments of the concordance between results from sense and antisense probes for the same SNP and concordance between results for the same SNPs obtained using arrays of different types. The same DNAs can be pooled multiple times, and the same pool can be analyzed multiple times, in order to further assess concordance.