There have also been recent successes in identifying genes associated with quantitative ocular traits important in POAG such as intraocular pressure (IOP), vertical cup disc ratio (CDR), optic disc area, and central corneal thickness (CCT). Genes known to be involved with these traits include atonal homolog 7 (ATOH7), transforming growth factor, beta receptor III (TGFBR3), SIX homeobox 1 (SIX1), and caspase recruitment domain family, member 10 (CARD10) with optic disc size and vertical cup disc ratio [13-15], as well as zinc finger protein 469 (ZNF469), A kinase (PRKA) anchor protein 13 (AKAP13), and collagen, type V, alpha 1 (COL5A1) with CCT [16-18].
