[8]. Association studies detect more common causes of disease and, more recently, several replicated genes have been detected using this method either on a genome-wide scale or by candidate gene analysis. Examples are a variant near the caveolin 1 (CAV1) and caveolin 2 (CAV2) genes on chromosome 7 [9,10]; transmembrane and coiled-coil domains 1 (TMCO1) and CDKN2B antisense RNA 1 (CDKN2B-AS1) [11], ELOVL fatty acid elongase 5 (ELOVL5), S1 RNA binding domain 1 (SRBD1) [12].
