Six SNPs were significantly associated with alcohol dependence defined by DSM-IV criteria (p < 0.05) (Table 2, Figure 2); five of these were located in GABRR2 from intron 1 to exon 9 and 1 was in intron 1 of GABRR1. Interestingly, rs282129 (p = 0.03) is a nonsynonymous coding SNP that leads to either a methionine or a threonine at amino acid 430 of GABRR2; the allele overtransmitted to the affected individuals encodes methionine. Eight additional SNPs (including 4 in the promoter to intron 1 region of GABRR2 and 1 upstream of GABRR1) demonstrated suggestive association (0.05 < p ≤ 0.10).
