SNP coverage was further assessed using Tagger (de Bakker et al., 2005); 61 of the SNPs were included in the HapMap database and could, therefore, be analyzed. In the CEU population, these 61 SNPs gave a mean r2 of 0.79 with a total of 250 HapMap SNPs in the region; 65% of the SNPs in the region were captured at r2 ≥ 0.8 and 84% at r2 ≥ 0.5. The 8 additional SNPs we genotyped that were not included in the HapMap database would further increase the coverage of this region. Thus, the SNPs we genotyped provide very good coverage of the variation in the GABRR1-GABRR2 gene cluster and adjacent genes.
