GABRR1 and GABRR2 are in a head-to-tail orientation spanning 137 kb on chromosome 6q (Figure 1). Based on the LD pattern, we analyzed 69 SNPs in the region extending 31 kb upstream of GABRR2 to the adjacent gene UBE2J1, and 95 kb downstream of GABRR1; this 263 kb region included three additional genes, PM20D2, SRrp35 and PNRC1 (Figure 1). The mean minor allele frequency (MAF) was 0.29, with a standard deviation ± 0.11 and a range from 0.06 to 0.50 (Table 2). The LD pattern in our sample is similar to that in the HapMap CEU (CEPH European) database.
