Given the association observed between AUDs and beta EEG in this and previous studies (Rangaswamy et al., 2004), we conducted a secondary analysis in which we repeated the initial GWAS of beta EEG, adjusting for DSM-V AUD severity. Results produced similar findings as the primary analyses; however, all p-values were slightly less significant. This suggests that the association of rs2252790 and beta EEG is not explained entirely by AUD; however, there may be an interaction among DSE variants, DSM-V AUD severity, and beta EEG. To comment on this more conclusively, future studies employing longitudinal data should assess the interaction of DSM-V AUD symptoms, DSE variants, and beta EEG.
