Based on previous physical, co-expression, co-localization and pathway gene-gene interactions observed in the literature, GeneMANIA indicated that DSE is involved in a network of genes integral to membrane organization (Table 2). Given that scalp electrodes record potential differences that are caused by postsynaptic potentials in the cell membrane of cortical neurons, the relation between genes critical in cellular membrane organization and EEG seems broadly plausible. Several genes in this network have been previously linked to phenotypes of relevance to beta EEG and related traits (i.e., cognitive performance, bipolar disorder, AUD). For example, variants within DSEL (Dermatin Sulfate epimerase-like) have been associated with cognitive performance (Need et al., 2009), depression (Shi et al., 2011), and bipolar disorder (Goosens et al., 2003). Each of these phenotypes have been linked to variation in beta rhythms (cognitive performance (Klimesch, 1999); depression (Zotev et al., 2014); bipolar disorder (Andersson et al., 2008). In the present study, we find evidence of association among many variants within this DSE gene network and beta EEG, with the most robust associations (empirical p<0.05) observed for ZEB2, MCTP1, RND3, and
