of insulin secretion by glucagon-like peptide 1′ and ‘glucagon signalling in metabolic regulation’), mTOR signalling (which affects cell growth in response to nutrient intake via insulin and growth factors25), and gene sets overlapping the neurotrophin signalling pathway identified by MAGENTA were also enriched, although not as significantly as other CNS processes (Fig. 2d). DEPICT also identified significant enrichment for additional cellular components and processes: calcium channels, MAP kinase activity, chromatin organization and modification, and ubiquitin ligases.
