Third, we manually reviewed literature related to all 405 genes within 500 kb and r2 > 0.2 of the 97 index SNPs. We classified these genes into one or more biological categories, and observed 25 categories containing three or more genes (Supplementary Table 22). The largest category comprised genes involved in neuronal processes, including monogenic obesity genes involved in hypothalamic function and energy homeostasis, and genes involved in neuronal transmission and development. Other processes highlighted by the manual literature review included glucose and lipid homeostasis and limb development, which were less notable in the above methods, but may still be related to the underlying biology of BMI.
