Chunk #38 — Materials and methods — Statistical analysis — Bayesian logistic regression

Source

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

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yes

Text

Let i index gene target-indication pairs (gi, ti), i = 1, …, N. Let yi ∈ {0, 1} be 1 if pair i is found in at least one US/EU approved drug and 0 otherwise. Let X be an N × d design matrix where d is the number of non-genetic predictors with ith row xi′. yi∼indepBernoulli(logit-1(α+ηi+xi′β))i=1,…,N where ηi={∑j=0pγjEC(gi,ti)jthereexists(g,t)∈Asuchthatg=gi0otherwise