Chunk #39 — Materials and methods — Statistical analysis — Bayesian logistic regression

Source

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

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yes

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Our choice of p = 2 is supported by WAIC [33] [34]. Predictors in X were top-level MeSH category, target class, estimated time the target has been under development, and RVIS score [17]. Details are provided in S5 Text. Priors were α∼N(μa,σa2); βj∼iidN(0,σb2)j=1,…,d γj∼iidN(0,σg2)k=0,1,2