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Chunk #15 — Methods — Literature search, study selection, and data extraction

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A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder.
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To estimate the robustness of the results to potential null findings, we used a calculation of the Fail-Safe N (FSN) adapted for ALE as described by Acar and colleagues [36]. Here, the FSN is defined as the amount of counterevidence (randomly generated study coordinates) that can be added to a meta-analysis before the results of that meta-analysis are altered.