additional mechanisms may be involved, for example, FOXP2 (expressed at high levels in BP, but not control neurons) binds the DISC1 promoter,65 thereby potentially affecting cell migrations and cortical layering. There were no obvious differences in the expression of transcripts for Hedgehog, Wnt or BMP family members between groups, but the significant increase in transcripts encoding transforming growth factor-β family members in control iPSC may suggest a mechanism underlying the observed differences in dorsal/ventral neuronal phenotypes between groups.
