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Chunk #10 — RESULTS — Genetic effects on risk of type 2 diabetes

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Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
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with those in the highest quintile of the score no longer being at significantly greater risk of diabetes relative to those in the lowest quintile (OR 1.22; 95% CI 0.92–1.62). The ROCAUC for the model including age and sex (ROCAUCs = 0.6382) improved significantly when the nine SNPs were added to the model (ROCAUCs = 0.6654) (P < 0.0001). However, BMI explained all the predictive power attributable to the SNPs (ROCAUCs: age, sex and BMI = 0.8236 versus age, sex, BMI and SNPs = 0.8236).