The risk of type 2 diabetes was significantly increased across the spectrum of the GBS following adjustment for age and sex (linear P < 0.0001). For each SD unit increase in the score, the risk of diabetes increased significantly (OR = 1.17; 95% CI 1.09–1.27), with those in the highest quintile of the GBS (n = 193/594 cases/controls) being at 1.55 (95% CI 1.21–1.99) greater risk of type 2 diabetes than those in the lowest quintile (n = 130/655 cases/controls). When all SNPs were simultaneously entered into the model, the unadjusted ROCAUC for type 2 diabetes was 0.5643 (P < 0.0001), which was significantly larger than any of the individual SNP ROCAUCs. The ROCAUC for the GBS was 0.5524, which did not differ from the model containing all SNPs (P difference = 0.14). Additional adjustment for BMI attenuated the association, with those in the highest quintile of the score no longer being at significantly greater risk of diabetes relative to those in the lowest quintile (OR 1.22; 95% CI 0.92–1.62). The ROCAUC for the model including age and sex (ROCAUCs
