Table 5 shows the associations between each of the nine obesity-risk variants and type 2 diabetes. In models adjusted for age and sex, four variants were significantly associated with type 2 diabetes risk (FTO rs1121980: P = 0.013; MC4R rs17782313: P = 0.009; GNPDA2 rs10938397: P = 0.028; TMEM18 rs6548238: P = 0.007). A tendency for association with diabetes was observed for the SH2B1 rs7498665 variant (P = 0.06). After additional adjustment for BMI, none remained statistically significant. Although PCSK1 rs6235 was not significantly associated with diabetes in the age- and sex-adjusted models (P = 0.21), additional adjustment for BMI rendered a nominally significant protective effect for this variant (P = 0.04).
