suggesting that the easier to collect SRE can be used in large-scale studies to measure LR (Schuckit et al., 1997a, Schuckit et al., 2009b, Schuckit et al., 1997b). SRE scores also have an one year test-retest correlation between 0.72-0.82 and five-year retest of 0.66, indicating high levels of reliability (Schuckit et al., 2009, Schuckit et al., 1997b). Their predictive validities regarding future heavy drinking and alcohol problems across different populations and sexes in studies conducted in the U.S., U.K., and Switzerland are also consistent (Daeppen et al., 2000, Kalu et al., 2012, Pedersen and McCarthy, 2013, Schuckit et al., 2007, Schuckit et al., 2008a, Schuckit et al., 2008b, Wall et al., 1999). These studies cumulatively indicate that an individual’s LR, as measured by the SRE, could serve as an additional risk marker for the development of problem drinking, and can be a useful tool in efforts to personalize prevention and treatment (Schuckit et al., 2016).