Both AD and LR (self-report or alcohol challenge results) are heritable (Viken et al., 2003, Kalu et al., 2012, Heath et al., 1999). While there have been numerous efforts to identify genetic variants for AD (Walters et al., 2018), there have been only a few studies examining the genetic contributions to SRE. Two linkage studies, one using 745 European ancestry individuals (included in this study) (Schuckit et al., 2001) and another in American Indians (Ehlers et al., 2010), detected modest evidence of linkage. Recently, a meta-analysis of genomewide association studies (GWAS) of SRE score of the first 5 times of drinking (SRE-5) did not identify genomewide significant loci (Edwards et al., 2018). Genetic analyses of the average SRE scores across the three time periods (SRE-T) have been limited to candidate gene studies (Schuckit, 2018). A recent analysis showed that polygenic risk scores derived from a GWAS of alcohol consumption in a large U.K. population of older adults explained minimal variance in SRE-T (Johnson and Agrawal, 2018) suggesting that even at a polygenic level, SRE scores might be associated with unique
